Covid vaccine rates are falling in U.S.

A sign advertises Covid vaccine shots at a Walgreens Pharmacy in Somerville, Massachusetts, on Aug. 14, 2023. Brian Snyder | Reuters Three years into the Covid-19 pandemic, few Americans are rolling up their sleeves to get a Covid vaccine.  Only 15.7% of U.S. adults had received the newest Covid shots from Pfizer, Moderna and Novavax … Read more

Could CRISPR cure HIV someday?

In an ongoing clinical trial, researchers are testing whether just one dose of a new gene therapy that might effectively cure human immunodeficiency virus (HIV) infections is safe in humans.  The therapy, named EBT-101, involves using CRISPR-Cas9 gene editing to treat HIV. This potential treatment strategy has been studied in animal models since the development … Read more

Israel-Hamas war live: US ‘intensely focused’ on hostage release as UK PM says truce breakdown ‘deeply disappointing’ | Israel-Hamas war

US ‘intensely focused’ on hostage release, says Blinken as he blames Hamas for ending truce The US remains “intensely focused” on freeing all the hostages held in Gaza despite the end of a ceasefire agreement between Israel and Hamas, the US secretary of state, Antony Blinken, has said. Blinken, speaking to reporters on Friday before … Read more

Tailor made: the art of therapeutic mRNA design

Barbier, A. J., Jiang, A. Y., Zhang, P., Wooster, R. & Anderson, D. G. The clinical progress of mRNA vaccines and immunotherapies. Nat. Biotechnol. 40, 840–854 (2022). Article  CAS  PubMed  Google Scholar  Lindsay, K. E. et al. Visualization of early events in mRNA vaccine delivery in non-human primates via PET–CT and near-infrared imaging. Nat. Biomed. … Read more

Prone Positioning During Extracorporeal Membrane Oxygenation in Patients With Severe ARDS: The PRONECMO Randomized Clinical Trial | Cardiology | JAMA

Key Points Question  Prone positioning may improve the outcome of patients with severe acute respiratory distress syndrome (ARDS), but is prone position superior to supine position among patients receiving venovenous extracorporeal membrane oxygenation (VV-ECMO) for severe ARDS? Findings  In this randomized clinical trial that included 170 patients primarily with COVID-19 who were undergoing VV-ECMO, successful … Read more