Israel’s Gaza Offensive Progresses, but Obstacles, Competing Timetables Remain :: Middle East Forum

Israel’s ground offensive in Gaza is making steady progress. They moved into the strip on 27 October after a sustained air campaign which paved the way for infantry, armoured and engineering units to enter. Despite military analysts predicting that Israel would sustain heavy combat losses, because of decent intelligence gathered in the preceding three weeks, … Read more

Microglia’s Crucial Role in Human Brain Development

Summary: Researchers discovered the essential role of microglia, brain immune cells, in early human brain development by incorporating them into lab-grown brain organoids. This breakthrough allows scientists to understand how microglia influence brain cell growth and development, potentially revolutionizing our understanding of brain development and disorders. The study reveals a unique pathway where microglia interact … Read more

Bacterial cGAS senses a viral RNA to initiate immunity

Bacterial strains and growth conditions The bacterial strains used in this study are listed in Supplementary Table 1. S. aureus strain RN422025 was grown at 37 °C with shaking (220 RPM) in brain heart infusion (BHI) broth, supplemented with chloramphenicol (10 μg ml−1) or erythromycin (10 μg ml−1) to maintain pC194-based24 or pE194-based plasmids40, respectively. Cultures were supplemented with chloramphenicol … Read more

Infant Brain Development and Social Interactions

Summary: A new study delves into infant brain development and its impact on social interactions and stress recovery during the first year of life. Through functional MRI scans and interactive tasks with mothers, researchers observe early neural patterns. One study reveals that greater brain network connectivity at 3 months correlates with improved infant-mother dyadic flexibility … Read more

Morning Report — Senate up next to avert shutdown; Biden meets Xi  

Editor’s note: The Hill’s Morning Report is our daily newsletter that dives deep into Washington’s agenda. To subscribe, click here or fill out the box below. Close Thank you for signing up! Subscribe to more newsletters here The latest in politics and policy. Direct to your inbox. Sign up for the Morning Report newsletter We’re focused today on tentative budgetary … Read more

Clostridioides difficile ferrosome organelles combat nutritional immunity

Pi, H. & Helmann, J. D. Ferrous iron efflux systems in bacteria. Metallomics 9, 840–851 (2017). Article  CAS  PubMed  Google Scholar  Imlay, J. A. Pathways of oxidative damage. Annu. Rev. Microbiol. 57, 395–418 (2003). Article  CAS  PubMed  Google Scholar  Chandrangsu, P., Rensing, C. & Helmann, J. D. Metal homeostasis and resistance in bacteria. Nat. Rev. … Read more

RSV cases rise in Massachusetts as hopes dim for broad access to new drug for babies

But no sooner had doctors started ordering the drug than the manufacturer, Sanofi, announced it would not be able to meet the demand. Last month’s hopes for a quick resolution of the supply problems with nirsevimab have been dashed. “It was optimistic thinking,” said Dr. Rick Malley, senior physician in infectious disease at Boston Children’s … Read more