Is Metformin a ‘Drug for All Diseases’?

As a front-line treatment for type 2 diabetes, metformin is among the most widely prescribed drugs in the United States. In 2021 alone, clinicians wrote more than 91 million orders for the medication — up from 40 million 2004. But is metformin just getting started? Emerging evidence suggests the drug may be effective for a … Read more

How indiscriminate Israeli fire killed half a family in Gaza

She almost died in an Israeli airstrike. What happened to her family was a mystery. CNN Special Report By Abeer Salman, Mohammad Al Sawalhi, Benjamin Brown, Mick Krever, Jomana Karadsheh, Ivana Kottasová, Gianluca Mezzofiore, Carlotta Dotto, Byron Manley and Lou Robinson, CNN Published February 28, 2024 The right side of Roba Abu Jibba’s face is … Read more

Your brain on menopause | On Point

Hot flashes. Brain fog. Sleep problems. Millions of women go through menopause each year. But what’s happening in the brain during this life transition? Today, On Point: The new science on menopause. Guests Lisa Mosconi, neuroscientist and director of the Women’s Brain Initiative at Weill Cornell Medicine. Author of the forthcoming book “The Menopause Brain: … Read more

Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance

Iliff, J. J. et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci. Transl. Med. 4, 147ra111 (2012). PubMed  PubMed Central  Google Scholar  Xie, L. et al. Sleep drives metabolite clearance from the adult brain. Science 342, 373–377 (2013). ADS  CAS  PubMed  Google … Read more

Michigan primary results: Biden wins but Gaza policy weakens his support

Editor’s note, February 28, 6:45 am ET: President Joe Biden won Michigan’s Democratic primary Tuesday night. With nearly all of the vote counted, about 13 percent went to “uncommitted.” The original story that follows was published February 27. Arab American activists and their allies are urging voters to cast ballots as “uncommitted” in Michigan’s Democratic … Read more

Multisensory gamma stimulation promotes glymphatic clearance of amyloid

Mice All animal experiments were conducted in accordance with National Institutes of Health (NIH) guidelines and were overseen by and adherent to the rules set forth by the Massachusetts Institute of Technology Institutional Animal Care and Use Committee. All of the animal holding rooms were maintained within temperature (18–26 °C) and humidity ranges (30–70%) described in … Read more

An atlas of epithelial cell states and plasticity in lung adenocarcinoma

Multi-regional sampling of human surgically resected LUADs and NL tissues Study participants were evaluated at the MD Anderson Cancer Center and underwent standard-of-care surgical resection of early-stage LUAD (I–IIIA). Samples from all patients were obtained from banked or residual tissues under informed consent and approved by MD Anderson institutional review board protocols. Residual surgical specimens … Read more

What Happened to Lula? | Foreign Affairs

Few leaders could claim, on taking office, to have induced sighs of relief from both Chinese President Xi Jinping and U.S. President Joe Biden. Yet in January 2023, that is exactly what Luiz Inácio Lula da Silva did. His narrow victory over Brazilian President Jair Bolsonaro, a right-wing extremist and an admirer of Donald Trump, … Read more